Skip to content
Ngunnawal Country, Australia35.28°S · 149.13°E

Systems architect

Bringing coherence to complex fields.

Across software, infrastructure, inference and computational science.

Joe Bones — Systems architect

J. Bones — AUS

01

About

One discipline, many domains.

Molecular scaffolds, infrastructure, data — for people.

More about me
01

Research, Data & Science

Atomic-scale simulation exposing the mechanics of disease.

02

Systems & Infrastructure

Foundations that hold their shape under load.

03

Applications & Product

Software that opens how people think.

Now building

EndPoint

PhD · Drug-discovery pipeline

One reproducible pipeline that turns fragmented protein structures into simulation-ready systems — so drug-discovery leads surface sooner.

See it on the projects page
Now building

BoneShell

Open source · Dev tooling

One command makes a fresh Mac or Linux machine fully home — your whole toolchain, version-controlled and carried between systems.

See it on the projects page

Projects

The same discipline, different domains.

Platform · CTOMVP

SelfTherapy

Mental-health support across web, iOS and Android.

Try the app
Platform · DefenceMVP

MindCompass

The same support translated for military minds.

Try the app
System · Defence

FABHUMS

Bridge structural-health monitoring. Sensors, hardware, operators — one interface.

Explore
Research · Nature 2022

TLR7 gain-of-function genetic variation causes human lupus

Structural impact of a gain-of-function mutation in the TLR7 immune receptor as a cause of human lupus — atomic-scale simulation informing real-world disease.

Read paper
Research · Science Adv. 2023

DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency

Computational biophysics on the DECTIN-1 immune-system protein as a modifier in CTLA-4 haploinsufficiency.

Read paper
Research · Nature Immunology 2026

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

How 2′-O-methyl-guanosine RNA fragments antagonise the TLR7 and TLR8 receptors to limit autoimmunity.

Read paper

Alongside

If the work resonates, say hello.

It's a practice I keep in the open. Bring a hard problem, a question, or just a conversation.

Start a conversation